Pediatric Acute Liver Failure
نویسندگان
چکیده
Pediatric acute liver failure (PALF) has recently become a subject of great interest when multiple clusters non-A to non-E severe hepatitis in otherwise healthy young children with median age 2 years were reported around the world [...]
منابع مشابه
Chronic acetaminophen exposure in pediatric acute liver failure.
BACKGROUND Acetaminophen (N-acetyl-p-aminophenol [APAP]) is a widely used medication that can cause hepatotoxicity. We examined characteristics and outcomes of children with chronic exposure (CE) to APAP in the multinational Pediatric Acute Liver Failure (PALF) Study. METHODS A total of 895 children enrolled from 2002 to 2009 were grouped by APAP exposure history as: CE (received multiple dos...
متن کاملAcute liver failure in children: the first 348 patients in the pediatric acute liver failure study group.
OBJECTIVES To determine short-term outcome for children with acute liver failure (ALF) as it relates to cause, clinical status, and patient demographics and to determine prognostic factors. STUDY DESIGN A prospective, multicenter case study collecting demographic, clinical, laboratory, and short-term outcome data on children from birth to 18 years with ALF. Patients without encephalopathy wer...
متن کاملValidity of pediatric index of mortality 2 (PIM2) score in pediatric acute liver failure
Introduction Pediatric acute liver failure (PALF) is an aggressive clinical syndrome in which a previously healthy child rapidly loses hepatic function and can become critically ill within days [1,2]. The mortality rate has been reported as high as 70% without a liver transplant, which is the only curative treatment to date [3]. However, when the current criterion of an international normalized...
متن کاملAcute liver failure.
Acute liver failure in children is associated with a high mortality. Most cases in our setup are due to water borne hepatotropic viruses HAV and HEV. The clinician must be aware of the earliest and the subtle signs of acute liver failure to identify cases early enough and institute supportive therapy. Focus of therapy has to be on prevention, early recognition and appropriate management of comp...
متن کاملAcute Liver Failure
Acute liver failure (ALF) (sometimes referred to as fulminant hepatic failure) is a clinical syndrome from a variety of causes resulting from rapid loss in hepatocyte function, typically associated with coagulopathy and encephalopathy in a patient without preexisting liver disease or cirrhosis. Cerebral edema is a cardinal feature and may produce uncal herniation, yielding brain stem compressio...
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ژورنال
عنوان ژورنال: Pediatric Reports
سال: 2023
ISSN: ['2036-749X', '2036-7503']
DOI: https://doi.org/10.3390/pediatric15030039